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Genetic Engineering and Molecular Studies of In...
40,99 € *
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This book reveals some details of research done at Marshall University, USA, involving functional aspects of pancreatic beta cells in several experimental models: avian, transgenic mice, and beta-cell lines. In this book you will gain some knowledge of genetic engineering approaches to improve beta-cell insulin secretion which could be applied to manage models and cases of diabetes mellitus. This work is presented as three separate chapters. The first chapter aims to gain an understanding of the expression pattern of CaBP28k in the chicken pancreas and to explore its spatial relationships with insulin in beta cells. The second chapter is to identify the influence of CaBP28k-ablation on the dynamics of [Ca2+]i in response to glucose stimulation in murine beta cells of CaBP28k-KO mice pancreatic islets and wildtype islets. The third chapter is an attempt to elucidate the genomic and non-genomic effects of in vitro CaBP28k-ablation in a cultured beta-cell line. It highlights the effects on the gene expression profile and insulin secretory responses from cultured rat insulinoma cell lines using antisense oligonucleotides transfection.

Anbieter: buecher
Stand: 05.04.2020
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Clinical Cardiac Electrophysiology in the Young
109,99 € *
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This book focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young. It represents a compilation of the clinical course, electrophysiologic studies, pharmacological management, and transcatheter ablation therapy in patients from infancy through young adulthood. Topics include the mechanism, ECG characteristics, electrophysiologic findings, treatment, and prognosis of tachyarrhythmias and bradyarrhythmias; specialized subjects including syncope, cardiac pacemakers, and implantable cardiac defibrillators; pharmacology of antiarrhythmic agents; and the roles of allied healthcare professionals in the management of arrhythmias in the young. This revised edition includes new or expanded chapters on the molecular biology mechanisms that underlie the structure and function of the cardiac conduction system; new navigation technologies for detecting cardiac arrhythmias while minimizing radiation exposure; genetic disorders of the cardiac impulse; and sudden cardiac death in the young, particularly athletes. Featuring contributions from practicing clinical cardiac electrophysiologists affiliated with the Michigan Congenital Heart Center at the University of Michigan, Clinical Cardiac Electrophysiology in the Young, Second Edition, is a premier reference for cardiologists, residents, and medical students.

Anbieter: buecher
Stand: 05.04.2020
Zum Angebot
Clinical Cardiac Electrophysiology in the Young
109,99 € *
ggf. zzgl. Versand

This book focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young. It represents a compilation of the clinical course, electrophysiologic studies, pharmacological management, and transcatheter ablation therapy in patients from infancy through young adulthood. Topics include the mechanism, ECG characteristics, electrophysiologic findings, treatment, and prognosis of tachyarrhythmias and bradyarrhythmias; specialized subjects including syncope, cardiac pacemakers, and implantable cardiac defibrillators; pharmacology of antiarrhythmic agents; and the roles of allied healthcare professionals in the management of arrhythmias in the young. This revised edition includes new or expanded chapters on the molecular biology mechanisms that underlie the structure and function of the cardiac conduction system; new navigation technologies for detecting cardiac arrhythmias while minimizing radiation exposure; genetic disorders of the cardiac impulse; and sudden cardiac death in the young, particularly athletes. Featuring contributions from practicing clinical cardiac electrophysiologists affiliated with the Michigan Congenital Heart Center at the University of Michigan, Clinical Cardiac Electrophysiology in the Young, Second Edition, is a premier reference for cardiologists, residents, and medical students.

Anbieter: buecher
Stand: 05.04.2020
Zum Angebot
Genetic Engineering and Molecular Studies of In...
59,00 € *
ggf. zzgl. Versand

This book reveals some details of research done at Marshall University, USA, involving functional aspects of pancreatic beta cells in several experimental models: avian, transgenic mice, and beta-cell lines. In this book you will gain some knowledge of genetic engineering approaches to improve beta-cell insulin secretion which could be applied to manage models and cases of diabetes mellitus. This work is presented as three separate chapters. The first chapter aims to gain an understanding of the expression pattern of CaBP28k in the chicken pancreas and to explore its spatial relationships with insulin in beta cells. The second chapter is to identify the influence of CaBP28k-ablation on the dynamics of [Ca2+]i in response to glucose stimulation in murine beta cells of CaBP28k-KO mice pancreatic islets and wildtype islets. The third chapter is an attempt to elucidate the genomic and non-genomic effects of in vitro CaBP28k-ablation in a cultured beta-cell line. It highlights the effects on the gene expression profile and insulin secretory responses from cultured rat insulinoma cell lines using antisense oligonucleotides transfection.

Anbieter: Dodax
Stand: 05.04.2020
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Outcome Predictors In Patients with Renal Cell ...
71,90 € *
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During the past decade, there have been important progresses and innovations in both basic and clinical fields of renal cell carcinoma. Major advances have been observed in the understanding of pathogenesis of renal cell carcinoma both at molecular and genetic levels. Improvements in imaging technology, including computerized scan and magnetic resonance imaging, has allowed accurate and detailed preoperative staging. Surgical management was revolutionized with the widespread use of nephron sparing surgery as well as the introduction of laparoscopic and robotic techniques. New treatment modalities were introduced to the market such as tumor ablation and active surveillance. Recently, the approval of new drugs targeting specific carcinogensis pathways had improved survival in patients with metastatic disease. Herein, we reviewed changes in our knowledge in terms of pathogenesis, surgical and medical management of renal cell carcinoma. We also revisited clinical and pathological factors that govern outcome of renal cell carcinoma.

Anbieter: Dodax
Stand: 05.04.2020
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Mouse Molecular Embryology. Vol.1
181,89 € *
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In Mouse Molecular Embryology: Methods and Protocols , expert researchers in the field detail many of the protocols used to study mouse embryology. These include protocols and techniques that are "close to the embryo": such as, manipulating embryonic gene expression, culturing explanted embryonic tissue and harvesting embryonic RNA. With additional chapters on fluorescence imaging, lineage tracing, and genetic ablation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Mouse Molecular Embryology: Methods and Protocols seeks to aid scientist in the further study of mouse embryo and its relation to other aspects of biological research.

Anbieter: Dodax
Stand: 05.04.2020
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Pineal, Pituitary, and Spinal Tumors
181,89 € *
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As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods.Volume 12: Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Anbieter: Dodax
Stand: 05.04.2020
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Hypertrophic Cardiomyopathy
161,98 € *
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This extensively updated edition provides a comprehensive review of hypertrophic cardiomyopathy, the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level. The disease produces abnormal and oftentimes focal hypertrophy on a macroscopic level that further impairs cardiac performance and may lead to life-threatening arrhythmias. This edition provides a practical approach, establishing evidence-based best practice for all scenarios.Hypertrophic Cardiomyopathy provides readers with key points and critical clinical pearls to assist them in managing patients. New chapters have been included on managing hypertension, sleep apnea, coronary artery disease, structural and congenital disease, nutrition and pharmacotherapies. All aspects of treatment are covered - medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) - in addition to genetics, family screening, lifestyle concerns, and athletic screening. The practical approach has been reinforced with an expanded emphasis on creating a Center of Excellence, how to facilitate the multi-disciplinary approach, and on case-based reviews and discussions, with each chapter ending with a post-test.This book is an essential text for cardiology professionals from trainee to board-certified physician, and includes important information for interventional cardiologists, cardiac surgeons, cardiac imagers, critical care physicians, sports medicine physicians, genetic counsellors, and electrophysiologists.

Anbieter: Dodax
Stand: 05.04.2020
Zum Angebot
Clinical Cardiac Electrophysiology in the Young
149,79 € *
ggf. zzgl. Versand

This book focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young. It represents a compilation of the clinical course, electrophysiologic studies, pharmacological management, and transcatheter ablation therapy in patients from infancy through young adulthood. Topics include the mechanism, ECG characteristics, electrophysiologic findings, treatment, and prognosis of tachyarrhythmias and bradyarrhythmias, specialized subjects including syncope, cardiac pacemakers, and implantable cardiac defibrillators, pharmacology of antiarrhythmic agents, and the roles of allied healthcare professionals in the management of arrhythmias in the young. This revised edition includes new or expanded chapters on the molecular biology mechanisms that underlie the structure and function of the cardiac conduction system, new navigation technologies for detecting cardiac arrhythmias while minimizing radiation exposure, genetic disorders of the cardiac impulse, and sudden cardiac death in the young, particularly athletes. Featuring contributions from practicing clinical cardiac electrophysiologists affiliated with the Michigan Congenital Heart Center at the University of Michigan, Clinical Cardiac Electrophysiology in the Young, Second Edition, is a premier reference for cardiologists, residents, and medical students.

Anbieter: Dodax
Stand: 05.04.2020
Zum Angebot